Oxford University has announced its first "massive open online course" (so-called Mooc) in a partnership with a U.S. online university network, according to BBC on Tuesday.
Until now Oxford has not offered such Mooc courses, which have grown in popularity with hundreds of universities and millions of students.
It is going to run an economics course partnered with online platform edX, set up by Harvard University and Massachusetts Institute of Technology.
The emergence of Mooc courses in recent years has been a major phenomenon in higher education, particularly in the United States.
Their supporters argued that putting courses online would make them more accessible and affordable - while sceptics doubted that teaching and the exchange of ideas in seminars could be replicated on the internet.
They also warned of the high drop-out rate from Moocs and that students were unlikely to get a full degree.
Oxford has offered many resources online, including through the iTunes U service and also its department for continuing education.
But until now it has not engaged in the type of Mooc courses offered by the big online networks, such as edX and Coursera in the US and FutureLearn in the UK.
These provide free mini-courses, which can be accessed by students anywhere in the world.
Oxford has now announced that it will begin enrolling students for a course starting in February 2017 called "From Poverty to Prosperity: Understanding Economic Development".
It will be part of the edX online platform, which has nine million registered students and runs more than 900 online courses from universities including Harvard, MIT, Berkeley in the US, Peking in China and Sorbonne in France as well as Edinburgh and Imperial College London in the UK.
The course will examine the role that governments play in boosting economic development and will be led by Sir Paul Collier, professor of economics and public policy at the Blavatnik School of Government.
Ngaire Woods, Blavatnik's dean, said the online course would be "an effective way to expand access to knowledge beyond the classrooms of Oxford".