Authorization

Oncoinvent Announces Dosing of First Patient with Radspherin® in Phase 1 Clinical Trial

STOCKHOLM, June 2, 2020 /PRNewswire/ -- Oncoinvent AS, a clinical stage radiopharmaceutical company developing novel radioisotope-based therapies to provide new therapeutic options for cancer patients, today announced that the first patient has been dosed in the phase 1, first-in-human clinical trial of it's lead candidate compound Radspherin."Radspherin represents a promising new approach for treating patients with metastates to the peritoneal cavity from colorectal cancer that may potentially provide a better outcome with longer progression free survival for patients that undergo cytoreductive surgery together with hypertherm intraperitoneal chemotherapy," said Stein Gunnar Larsen, M.D., Section Leader Department of Surgical Oncology, Oslo University Hospital, Norway and lead clinical investigator in the trial. "We are always looking for opportunities to improve patient outcomes and give patients a better quality of life. Radspherin has demonstrated preclinical activity in a range of cancer models, and we are excited to further investigate it in this Phase 1 study.""Radspherin is a potentially transformative approach for a range of difficult-to-treat metastatic cancers," said A?yvind S. Bruland, M.D., Chief Medical Officer of Oncoinvent. "The mode of action of Radspherin is to deliver a lethal dose of short range alpha radiation to remaining tumour cells in the peritoneum after surgery. Radium-224 emits alpha particles with high linear energy transfer (LET). There are no known cellular resistance mechanisms to this type of ionizing radiation, which may therefore be effective against dormant and chemo-resistant cancer cells remaining after surgical resection of macroscopic visible tumours and thereby increase the prospect of a complete response. We believe it could provide a profound benefit for patients that are in dire need of new therapies." About the Study
See also:
Leave a comment
News
  • Latest
  • Read
  • Commented
Calendar Content
«    Июль 2020    »
ПнВтСрЧтПтСбВс
 12345
6789101112
13141516171819
20212223242526
2728293031