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ISCHEMIA-CKD Trial: Advanced Chronic Kidney Disease Patients Treated with Invasive Heart Procedures Show No Reduction in Rate of Cardiac Events

BROOKLYN, N.Y., Nov. 16, 2019 /PRNewswire/ --A Heart disease is the leading cause of death for the roughly 500 million people worldwide with chronic kidney disease (CKD). Yet such patients have been excluded from most of the major, relevant cardiovascular clinical trials that are meant to guide treatment approaches for them.
ISCHEMIA-CKD Trial: Advanced Chronic Kidney Disease Patients Treated with Invasive Heart Procedures Show No Reduction in Rate of Cardiac Events
Today, an international, federally funded study reported on comparing the value of two treatment strategies specifically for patients with advanced chronic kidney disease that also had significant, but stable disease in their coronary arteries. Presented November 16th at the American Heart Association's Scientific Sessions 2019, the study found that patients with CKD that underwent routine, invasive procedures a?? like stent implants or bypass surgery a?? when compared with patients that received only the lifestyle advice and medications (e.g. aspirin, statins), saw no reduction in risk for two disease-related outcomes: death and heart attack. In contrast, rates of certain outcomes such as stroke was increased in the invasive procedure group, although strokes immediately following the procedure were rare. Called ISCHEMIA-CKD (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches - Chronic Kidney Disease), the study also found that for patients with symptoms of angina a?? the chest pain caused by restricted blood flow to heart muscle a?? invasive treatments did not result in better, long-term symptom relief and quality of life than among those that received only "optimal medical therapy" (OMT), the term for medications and lifestyle advice.
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