Authorization

New Analysis from Landmark CREDENCE Study Shows the Efficacy and Safety Profiles of INVOKANA (canagliflozin) are Consistent Across Various Levels of Kidney Function

WASHINGTON, Nov. 9, 2019 /PRNewswire/ -- The Janssen Pharmaceutical Companies of Johnson & Johnson announced today results of an important new analysis from the landmark Phase 3 CREDENCE study, which found that INVOKANAA (canagliflozin) consistently reduced the risk of renal and cardiovascular (CV) events in patients with various levels of kidney function, or estimated glomerular filtration rates (eGFR*). This analysis showed that INVOKANAA provides a strong, consistent safety profile and efficacy at all tested eGFR levels. Specifically, greater renal absolute benefits were observed in those with the most advanced renal insufficiency (eGFR <60 mL/min/1.73 m2). Results from this secondary analysis were presented today in an oral presentation at the American Society of Nephrology (ASN) Kidney Week 2019 and build on the positive primary results from the Phase 3 CREDENCE study.
New Analysis from Landmark CREDENCE Study Shows the Efficacy and Safety Profiles of INVOKANA (canagliflozin) are Consistent Across Various Levels of Kidney Function
"We now know that the renal and cardiovascular benefits of canagliflozinAare preserved across a wide eGFR range from 90 to 30 mL/min/1.73 m2. Because they were at higher risk to begin with, the absolute benefit for preventing the progression of kidney disease was greater in patients who already had renal insufficiency," said CREDENCE study investigator Meg J. Jardine, M.B.B.S., Ph.D., Deputy Director, Renal & Metabolic Division, The George Institute for Global Health, and Associate Professor, Faculty of Medicine, University of New South Wales Sydney.a? "Importantly, there was no difference in the safety profile as eGFR decreased, which should provide physicians with even more confidence when prescribing canagliflozin across the broadest range of eGFR levels."CLICK TO TWEET: New analysis from CREDENCE shows consistent results in patients with T2D and DKD across multiple levels of kidney function #eGFR #CREDENCE https://ctt.ec/dTC2L+DKD affects 200 million people1 and is the fifth fastest-growing cause of death worldwide.2 By the time these type 2 diabetes patients are referred to a nephrologist, their DKD has often progressed to the point of needing dialysis. Once patients reach end-stage kidney disease (ESKD), their average five-year survival is less than 40 percent, largely due to CV-associated morbidity and mortality.3
See also:
Leave a comment
News
  • Latest
  • Read
  • Commented
Calendar Content
«     2019    »
 123
45678910
11121314151617
18192021222324
252627282930