Synlogic Announces Achievement of Milestone in Collaboration to Develop Synthetic Biotica?? Medicines to Treat Inflammatory Bowel Disease

Inc.,A (Nasdaq: SYBX) a clinical stage company applying synthetic
biology to beneficial microbes to develop novel, living medicines,A today
announced the advancement of Synthetic Biotic medicines to the lead
optimization stage in its collaboration with AbbVie,
a global biopharmaceutical company, to develop an oral treatment for
inflammatory bowel disease (IBD).

"We are delighted with the progress of our collaboration with AbbVie, a
world-class company with expertise in immunology and the development of
treatments for patients with inflammatory bowel disease,a?? said Aoife
Brennan, M.B, Ch.B., Synlogica??s president and chief executive officer
"Our collaboration has enabled us to broaden the reach of our platform
in inflammatory and autoimmune conditions while advancing our internal
pipeline in rare metabolic diseases.a??

"Synlogic is a leader in the use of synthetic biology for the
development of novel bacterial therapeutics," said, Lisa Olson Ph.D.,
Vice President, Immunology Research, AbbVie. "Synlogica??s Synthetic
Biotic platform has the potential to enable development of treatments
for inflammatory disorders, such as IBD. We are pleased with the
progress that our combined teams continue to make in the development of
this novel approach.a??

About Synlogic
Synlogic is pioneering the development of a
novel class of living medicines, Synthetic Biotic medicines, based on
its proprietary drug development platform. Synlogic leverages the tools
and principles of synthetic biology to genetically engineer beneficial
microbes to perform or deliver critical functions missing or damaged due
to disease. Synthetic Biotic medicines are designed to act locally and
have a systemic effect to address disease in patients. Synlogica??s two
lead programs, SYNB1020 and SYNB1618, are orally administered and target
hyperammonemia as a result of liver damage or genetic disease, and
phenylketonuria, respectively. Synlogic is also developing SYNB1891 as
an intratumorally-administered Synthetic Biotic medicine for the
treatment of cancer. In addition, the company is leveraging the broad
potential of its platform to create additional Synthetic Biotic
medicines for the treatment of liver disease, as well as inflammatory
and immune disorders including Synlogica??s collaboration with AbbVie to
develop Synthetic Biotic-based treatments for inflammatory bowel disease
(IBD). For more information, please visit

Forward-Looking Statements
This press release contains
"forward-looking statementsa?? that involve substantial risks and
uncertainties for purposes of the safe harbor provided by the Private
Securities Litigation Reform Act of 1995. All statements, other than
statements of historical facts, included in this press release regarding
strategy, future operations, future financial position, future revenue,
projected expenses, prospects, plans and objectives of management are
forward-looking statements. In addition, when or if used in this press
release, the words "may,a?? "could,a?? "should,a?? "anticipate,a?? "believe,a??
"estimate,a?? "expect,a?? "intend,a?? "plan,a?? "predicta?? and similar
expressions and their variants, as they relate to Synlogic may identify
forward-looking statements. Examples of forward-looking statements,
include, but are not limited to, statements regarding the potential of
Synlogica??s platform to develop therapeutics to address a wide range of
diseases, including: inflammatory and immune disorders, rare metabolic
diseases, liver disease and cancer; the future clinical development of
Synthetic Biotic medicines; the approach Synlogic is taking to discover
and develop novel therapeutics using synthetic biology; the potential of
Synlogica??s technology to treat cancer, hyperammonemia, and
phenylketonuria. Actual results could differ materially from those
contained in any forward-looking statement as a result of various
factors, including: the uncertainties inherent in the preclinical
development process; the ability of Synlogic to protect its intellectual
property rights; and legislative, regulatory, political and economic
developments, as well as those risks identified under the heading "Risk
Factorsa?? in Synlogica??s filings with the SEC. The forward-looking
statements contained in this press release reflect Synlogica??s current
views with respect to future events. Synlogic anticipates that
subsequent events and developments will cause its views to change.
However, while Synlogic may elect to update these forward-looking
statements in the future, Synlogic specifically disclaims any obligation
to do so. These forward-looking statements should not be relied upon as
representing Synlogica??s view as of any date subsequent to the date

Synlogic Announces Achievement of Milestone in Collaboration to Develop Synthetic Biotica?? Medicines to Treat Inflammatory Bowel Disease
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